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Bromotripyrrolidinophosphonium hexafluorophosphate 三吡咯烷基溴化鏻六氟磷酸鹽

規(guī)格: 97%
CAS: 132705-51-2
產(chǎn)品編號(hào): H39515
MDL: MFCD00077412
品牌: INFI

縮合劑系列產(chǎn)品

一個(gè)氨基酸的氨基與另一個(gè)氨基酸的羧基可以縮合成肽,形成的酰胺鍵在蛋白質(zhì)化學(xué)中稱為肽鍵。目前多肽合成中,主要采用羧基活化方法來(lái)完成縮合反應(yīng),最早使用的是將羧基活化為酰鹵、酰基疊氮、活性酯、對(duì)稱酸酐以及混合酸酐的方法,但是由于這些條件存在氨基酸消旋、反應(yīng)試劑危險(xiǎn)以及制備比較復(fù)雜等問(wèn)題,后來(lái)逐漸被縮合試劑取代。添加縮合劑則無(wú)需活化羧基,實(shí)驗(yàn)操作簡(jiǎn)單方便且綠色環(huán)保。在眾多縮合劑中,磷正離子縮合劑使得非天然氨基酸及有空間位阻的氨基酸順利的完成多肽合成,鹵代試劑例如PyBroP、BOP-Cl適合位阻大的氨基酸合成,避免發(fā)生外消旋作用(圖一)。縮合劑除了可以合成酰胺以外,還應(yīng)用于酯的合成,反應(yīng)條件更加溫和并且減少副反應(yīng)干擾。

圖一:Journal of Medicinal Chemistry, 2012, 55(23), 10610-10629

研峰科技擁有完整配套的研發(fā)生產(chǎn)設(shè)備,通過(guò)前期大量的工藝研究、公司規(guī)范有效的管控流程及智能管理系統(tǒng),實(shí)現(xiàn)了縮合劑系列產(chǎn)品穩(wěn)定量產(chǎn),質(zhì)量穩(wěn)定,滿足客戶要求,還可以根據(jù)客戶的需要進(jìn)行定制。詳細(xì)產(chǎn)品情況請(qǐng)致電客服人員(400-106-2016)進(jìn)行咨詢。

Chemical NameBromotripyrrolidinophosphonium hexafluorophosphate
CAS Number132705-51-2
Alfabeta NameBROMOTRIPYRROLIDINYLPHOSPHONIUMHEXAFLUOROPHOSPHATE V1(())--
MDL NumberMFCD00077412
Synonym BROMO-TRIS-PYRROLIDINO-PHOSPHONIUM HEXAFLUOROPHOSPHATE PyBroP\(rg BROMO-TRIS-PYRROLIDINO-PHOSPHONIUM HEXFLUOROPHOSPHATE PyBroP PYBROP(TM) Bromo-tris-pyrrolidino-phosphonium hexafluorophosphat Bromotri(1-pyrrolidinyl)phosphonium hexafluorophosphate, 97% Pybrop(Bromo-Tris-PyrrolidinophosphoniumHexafluorophosphate) 溴-三吡咯烷基磷代六氟磷酸酯 PYBROP(R) Bromotri(pyrrolidin-1-yl)phosphoniumhexafluorophosphate PYBROP 三吡咯烷基溴化六氟磷酸鹽 BROMOTRIPYRROLIDINOPHOSPHONIUM HEXAFLUOROPHOSPHATE PyBroP® Bromo-tris-pyrrolidino-phosphonium hexafluorophosphate ,97% Pyrrolidine phosphorus complex 三吡咯烷基溴化鏻六氟磷酸鹽
PubChem Substance ID160871368
Beilstein Registry Number6842340
EC Number000-000-0
Chemical Name Translation三吡咯烷基溴化鏻六氟磷酸鹽
Reaxys-RN6842340
GHS Symbol
Warnings IRRITANT
WGK Germany3
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防護(hù)手套/防護(hù)服/眼睛的保護(hù)物/面部保護(hù)物。
  • P362 Take off contaminated clothing and wash before reuse. 脫掉污染的衣服,清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 處理后要徹底洗凈雙手。
  • P302+P352+P332+P313+P362+P364
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉塵/煙/氣體/煙霧/蒸汽/噴霧。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或醫(yī)生/醫(yī)師。
  • P337+P313
    Hazard statements
    • H315 Causes skin irritation 會(huì)刺激皮膚
    • H314 Causes severe skin burns and eye damage 導(dǎo)致嚴(yán)重的皮膚灼傷和眼睛損傷
      Hazard Codes C Xi
      Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
      Signal word Danger Warning
      Safety Statements
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接觸后,立即用大量水沖洗并征求醫(yī)生意見(jiàn);
      • S37 Wear suitable gloves 戴適當(dāng)手套;
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴適當(dāng)?shù)姆雷o(hù)服、手套和眼睛/面保護(hù);
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 發(fā)生事故時(shí)或感覺(jué)不適時(shí),立即求醫(yī)(可能時(shí)出示標(biāo)簽);
      • S27 Take off immediately all contaminated clothing 立即脫掉全部污染的衣服;
      • S36 Wear suitable protective clothing 穿戴適當(dāng)?shù)姆雷o(hù)服;
        Risk Statements
        • R36/37/38 Irritating to eyes, respiratory system and skin 對(duì)眼睛、呼吸系統(tǒng)和皮膚有刺激性
        • R34 Causes burns 會(huì)導(dǎo)致灼傷
          Storage condition Moisture Sensitive -20°C <0°C 儲(chǔ)存溫度 -20°C
        • 多肽縮合劑,適宜于烴基雙取代的氨基酸,用于Depsipeptide的合成。
        • {SA}
        • 1. Vassiliki Theodorou, et al Tetrahedron 67 , 5630-5634, (2011)
        • {SA}
        • 2. Fu-An Kang, et al Chem. Commun. 46 , 1347-1349, (2010)
        • {SA}
        • 3. Fu-An Kang, et al J. Am. Chem. Soc. 130 , 1130-11302, (2008)
        • {SA}
        • 4. Jordi Alsina, et al Lett. Pept. Sci. 6 , 243-245, (1999)
        • {SA}
        • 5. J. Coste et al. J. Org. Chem. 59 , 2437, (1994)
        • {SA}
        • 6. T. Kurome et al. Tetrahedron 52 , 4327, (1996)
        • {ALF} Efficient peptide coupling agent for N-methylated amino esters for which coupling with a number of conventional reagents has proved ineffective or slow, and giving superior results to 1H-Benzotriazol-1-yl&#x00AD;oxytri(1-pyrrolidinyl)&#x00AD;phosphonium hexafluorophosphate, B25251, in this type of reaction: J. Org. Chem., 59, 2437 (1994). See Appendix 6.
        • {ALF} Can also be used to activate formamides, e.g. reaction of DMF with primary amines to yield formamidines: Tetrahedron Lett., 40, 5487 (1999).
        • 132705-51-2 H39515 Bromotripyrrolidinophosphonium hexafluorophosphate
三吡咯烷基溴化鏻六氟磷酸鹽
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          化學(xué)屬性

          Mol. FormulaC12H24BrF6N3P2
          Mol. Weight466
          TSCANo
          Density1.422
          Melting Point>100°C
          SolubilityDMF: 0.4 g/mL, clear
          Stability對(duì)濕度敏感

          *以上化合物性質(zhì)及應(yīng)用等信息僅供參考